Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:. Amlodipine and valsartan combination is used when a single medicine to lower your blood pressure is not enough.
It is also used as the first medicine to treat your condition if your doctor feels that you need to take more than one blood pressure medicine.
This medicine comes with a patient information insert. Read and follow the instructions carefully. Ask your doctor if you have any questions. In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium salt. Your doctor will tell you which of these are most important for you.
You should check with your doctor before changing your diet. Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.
Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease. The dose of this medicine will be different for different patients.
Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine.
Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects. Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
Kazuyuki Shimada. Select Format Select format. Permissions Icon Permissions. Abstract Background:. Valsartan , amlodipine , ambulatory blood pressure , morning blood pressure surge. Table 1 Patient baseline characteristics. Amlodipine Group. Valsartan Group. Age yr Open in new tab. Open in new tab Download slide. Differences in clinic systolic blood pressure and ambulatory systolic blood pressure before and after amlodipine and valsartan treatment.
Black bars , amlodipine group; white bars , valsartan group. Table 2 Blood pressure before and after treatment. Clinic SBP mm Hg 8. Effects of amlodipine and valsartan on hour and morning systolic blood pressure SBP by each dose.
Black bars , amlodipine group; dose from left to right : 2. Effects of amlodipine and valsartan on h and morning systolic blood pressure SBP by each dose. Solid lines indicate linear regression lines. Ambulatory blood pressure. Google Scholar Crossref. Search ADS. Prediction of mortality by ambulatory blood pressure monitoring versus screening blood pressure measurements: a pilot study in Ohasama.
Cardiovascular outcome in white-coat versus sustained mild hypertension: a year follow-up study. Predicting cardiovascular risk using conventional vs ambulatory blood pressure in older patients with systolic hypertension. Silent and clinically overt stroke in older Japanese subjects with white-coat and sustained hypertension.
Circadian variation and triggers of onset of acute cardiovascular disease. Cardiovascular risk and therapeutic intervention for the early morning surge in blood pressure and heart rate. Cardiac implications of the morning surge in blood pressure in elderly hypertensive patients: relation to arising time.
Morning surge in blood pressure as a predictor of silent and clinical cerebrovascular disease in elderly hypertensives: a prospective study. Stroke prognosis and abnormal nocturnal blood pressure falls in older hypertensives. Prognostic value of ambulatory blood-pressure recordings in patients with treated hypertension.
Differential effects of amlodipine on ambulatory blood pressure in elderly hypertensive patients with different nocturnal reductions in blood pressure. A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. Augmented diurnal variations of the cardiac renin-angiotensin system in hypertensive rats. Angiotensin II induces circadian gene expression of clock genes in cultured vascular smooth muscle cells.
Comparison of telmisartan v valsartan in the treatment of mild to moderate hypertension using ambulatory blood pressure monitoring. An ambulatory blood pressure monitoring study of the comparative antihypertensive efficacy of two angiotensin II receptor antagonists, irbesartan and valsartan.
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Amlodipine and valsartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Your blood pressure will need to be checked often.
Your kidney function may also need to be checked. You may have very low blood pressure while taking this medication. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. It may take up to 4 weeks for this medication to control your blood pressure. Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms.
You may need to use blood pressure medicine for the rest of your life. Blood pressure medication is only part of a complete treatment program that may also include diet, exercise, regular blood pressure checks, lifestyle changes, and other medications. Follow your doctor's instructions very carefully.
Use all medications as directed by your doctor. Do not change your doses or stop taking any of your medications without your doctor's advice. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Avoid driving or hazardous activity until you know how this medicine will affect you.
Your reactions could be impaired. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Tell your doctor about all your current medicines. Many drugs can affect amlodipine and valsartan, especially:.
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